Welcome To Genetics of Obesity Study (GOOS)
Within a given environment, some people put on weight very easily, whilst others remain thin. We aim to understand the key mechanisms that control body weight to inform the development of safe, effective weight loss interventions. We use genetic, molecular and clinical approaches to study cohorts of individuals with severe obesity and thinness.
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Latest News
Genetic study points to oxytocin as possible treatment for obesity and postnatal depression
Researchers found that disruption of the TRPC5 gene causes obesity, behavioural problems and, in mothers, postnatal depression. The discovery, reported in Cell, started with the investigation of two unrelated boys with severe obesity, anxiety, autism and behavioural...
Professor Sadaf Farooqi receives Outstanding Clinical Investigator Award
Professor Farooqi who has been announced as the recipient of the 2024 Outstanding Clinical Investigator Award from the Endocrine Society. She joins 14 other leading endocrinologists worldwide who have won prestigious 2024 Laureate Awards, the top honours in the field....
Deletion on Chromosome 16 leads to early-onset obesity and diabetes
Adults with a deletion involving SH2B1 develop early type 2 diabetes which is difficult to treat. In a paper published in the journal Cell Reports Medicine, we studied a part of chromosome 16 called 16p11.2 which can be deleted in people with obesity and/or learning...